11-deoxy-11-methylene Prostaglandin D2
货号：
12410-10mg 基本售价：
6384.0 元 规格：
10 mg
产品信息
概述| 货号 | 12410-10mg |
| 描述 | Prostaglandin D2(PGD2; Item No. 12010) is one of the five primary enzymatic prostaglandins derived directly from PGH2 (Item No. 17020). PGD2 is produced abundantly in the CSF by the lipocalin-type PGD synthase, and in the periphery by myeloid cells including mast cells and basophils by a second, leukocyte-type PGD synthase.1PGD2 is chemically unstable, and its use and analysis is complicated by its short in vivo half-life. 11-deoxy-11-methylene PGD2 is a novel, chemically stable, isosteric analog of PGD2 wherein the 11-keto group is replaced by an exocyclic methylene. In the PGE series, the analogous modification leads to a stable, somewhat less potent agonist which embodies the same uterine stimulant and cervical ripening activities as the parent prostaglandin.2 However, 11-deoxy-11-methylene PGD2 has been reported by one group to be essentially without agonist activity on human platelets, a DP1 receptor assay.3 The CRTH2-receptor actions of 11-deoxy-11-methylene PGD2 are not yet reported. |
| 别名 | 11-deoxy-11-methylene PGD2; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Urade, Y., and Hayaishi, O. Prostaglandin D synthase: Structure and function. Vitamins and Hormones 58, 89-120 (2000).
2.Borten, M.,DiLeo, L.A., and Friedman, E.A. Low-dose prostaglandin E2 analogue for cervical dilations prior to pregnancy termination. American Journal of Obstetics and Gynecology 150, 561-565 (1984).
3.Torisawa, Y.,Yamaguchi, T.,Sakata, S., et al. Synthesis of 11-deoxo-11-methylene-prostaglandin D2 and its derivatives. Chemical & Pharmaceutical Bulletin 33(10), 4625-4628 (1985).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 350.5 |
| 分子式 | C21H34O4 |
| CAS号 | 100648-29-1 |
| 稳定性 | ≥ 1 year |
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