AM80
货号：
71770-50mg 基本售价：
6370.0 元 规格：
50 mg
产品信息
概述| 货号 | 71770-50mg |
| 描述 | AM80 is a retinoic acid receptor agonist that is selective for RARα (Kd = 62 nM; AC50 = 1.46 nM) compared to RARβ (Kd = 280 nM; AC50 = 6.87 nM) and RARγ (Kd = 816 nM; AC50 = 148.7 nM).1 It demonstrates greater specific binding to RARα compared to retinoic acid (Item No. 11017), which exhibits little selectivity across RARα, β, or γ.2,1 AM80 exhibits antiproliferative effects against acute promyelocytic leukemia cells, inducing human promyelocytic leukemia HL-60 cell differentiation with an ED50 value of 0.79 nM.3,2 It has also been shown to suppress the growth of other myeloid and lymphoid malignant cells.2 |
| 别名 | Amnolake;NSC 608000;Retinobenzoic Acid;Tamibarotene; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bernard, B.A.,Bernardon, J.M.,Delescluse, C., et al. Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor γ. Biochemical and Biophysical Research Communications 186(2), 977-983 (1992).
2.Jimi, S.,Mashima, K.,Matsumoto, T., et al. RARα is a regulatory factor for Am-80-induced cell growth inhibition of hematologic malignant cells. International Journal of Oncology 31(2), 397-404 (2007).
3.Eyrolles, L.,Kagechika, H.,Kawachi, E., et al. Retinobenzoic Acids. 6. Retinoid antagonists with a heterocyclic ring. Journal of Medicinal Chemistry 37, 1508-1517 (1994).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 351.4 |
| 分子式 | C22H25NO3 |
| CAS号 | 94497-51-5 |
| 稳定性 | ≥ 2 years |
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