5-POHSA-d14
货号：
17196-1mg 基本售价：
6370.0 元 规格：
1 mg
产品信息
概述| 货号 | 17196-1mg |
| 描述 | 5-POHSA-d14 contains 14 deuterium atoms at the 2, 2, 3, 3, 4, 4, 5, 5, 6, 6, 7, 7, 8, and 8 positions. It is intended for use as an internal standard for the quantification of 5-POHSA (Item No. 17114) by GC- or LC-mass spectrometry. Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are newly identified endogenous lipids regulated by fasting and high-fat feeding and associated with insulin sensitivity in mice.1 Structurally these esters are comprised of a C-16 or C-18 fatty acid (e.g., palmitoleic, palmitic, oleic, or stearic acid) linked to either a C-16 or C-18 hydroxy substituent. 5-POHSA is a FAHFA consisting of palmitoleic acid esterified at the 5th carbon of hydroxy stearic acid. The levels of POHSA are significantly elevated in serum of glucose tolerant AG4OX mice, which overexpress the Glut4 glucose transporter specifically in adipose tissue.1 As other FAHFA improve glucose tolerance, stimulate insulin secretion, and have anti-inflammatory effects, 5-POHSA may be a bioactive lipid with roles in metabolic syndrome and inflammation.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Yore, M.M.,Syed, I.,Moraes-Vieira, P.M., et al. Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. Cell. 159(2), 318-332 (2014).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% deuterated forms (d1-d14) |
| 计算分子量 | 551 |
| 分子式 | C34H50D14O4 |
| 稳定性 | ≥ 1 year |
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