Sucrose octasulfate (potassium salt)
货号：
16382-5g 基本售价：
6370.0 元 规格：
5 g
产品信息
概述| 货号 | 16382-5g |
| 描述 | Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum−sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury.1 It can bind to exosite II of thrombin (KD = ~1.4 µM) and inhibit its catalytic activity (IC50 = 4.5 µM) and, as such, has been used as a surrogate for heparin.2 Furthermore, SOS has been shown to inhibit tumor growth in mouse melanoma and lung carcinoma models by preventing fibroblast growth factor 2 (FGF-2) binding to endothelial cells and also by removing any pre-bound FGF-2 from these cells (IC50 = ~2 µg/ml).3 |
| 别名 | SOS;Sucrosofate potassium; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Furukawa, O.,Matsui, H. and Suzuki, N. Effects of sucralfate and its components on acid- and pepsin-induced damage to rat gastric epithelial cells. Japanese Journal of Pharmacology 75(1), 21-25 (1997).
2.Desai, B.J.,Boothello, R.S.,Mehta, A.Y., et al. Interaction of thrombin with sucrose octasulfate. Biochemistry 50(32), 6973-6982 (2011).
3.Fannon, M.,Forsten-Williams, K.,Nugent, M.A., et al. Sucrose octasulfate regulates fibroblast growth factor-2 binding, transport, and activity: Potential for regulation of tumor growth. J.Cell Physiol. 215(2), 434-441 (2008).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 1287.5 |
| 分子式 | C12H14O35S8 • 8K |
| CAS号 | 73264-44-5 |
| 稳定性 | ≥ 2 years |
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