| 货号 | 16267-10mg |
| 描述 | Dolastatin 10 is a natural antimitotic and antineoplastic agent that binds to tubulin and inhibits tubulin polymerization.1 Monomethyl Auristatin E (MMAE) is a synthetic analog of dolastatin 10 that similarly inhibits tubulin polymerization and exhibits potent cytotoxicity. It is commonly conjugated with monoclonal antibodies directed at antigens specific to cancer cells for tumor-directed cytotoxicity.2,3 MMAE is typically coupled to the antibody via a protease-cleavable linker, allowing separation of the drug from the antibody following intracellular localization.3,4 |
| 别名 | Brentuximab vedotin;MMAE; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kingston, D.G.I. Tubulin-interactive natural products as anticancer agents. Journal of Natural Products 72(3), 507-515 (2009). 2.Francisco, J.A.,Cerveny, C.G.,Meyer, D.L., et al. cAC10-vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity. Blood 102, 1458-1465 (2003). 3.Tse, K.F.,Jeffers, M.,Pollack, V.A., et al. CR011, a fully human monoclonal antibody-auristatin E conjugate for the treatment of melanoma. Clinical Cancer Research 12(4), 1373-1382 (2006). 4.van de Donk, N.W.C.J. and Dhimolea, E. Brentuximab vedotin. mAbs 4(4), 458-465 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 718 |
| 分子式 | C39H67N5O7 |
| CAS号 | 474645-27-7 |
| 稳定性 | ≥ 2 years |
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