| 货号 | 14914-50mg |
| 描述 | Ionotropic glutamate receptors can be divided into three groups, depending on whether they are activated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), kainate, or N-methyl-D-aspartate (NMDA). NBQX is a water-soluble receptor antagonist which targets both AMPA- and kainate-sensitive glutamate receptors (IC50 = 0.15 and 4.8 µM, respectively).1 It does not block the NMDA-sensitive glutamate receptor (IC50 = ≥ 90 µM).1 NBQX can be used in isolated neurons, tissues, or in vivo.2,3,4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Sheardown, M.J.,Nielsen, E.O.,Hansen, A.J., et al. 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: A neuroprotectant for cerebral ischemia. Science 247(4942), 571-574 (1990). 2.Sylantyev, S.,Savtchenko, L.P.,Ermolyuk, Y., et al. Spike-driven glutamate electrodiffusion triggers synaptic potentiation via a homer-dependent mGluR-NMDAR link. Neuron 77(3), 528-541 (2013). 3.Bertollini, C.,Murana, E.,Mosca, L., et al. Transient increase in neuronal chloride concentration by neuroactive aminoacids released from glioma cells. Front.Mol.Neurosci. 5, 100 (2012). 4.Paterson, N.E.,Malekiani, S.A.,Foreman, M.M., et al. Pharmacological characterization of harmaline-induced tremor activity in mice. European Journal of Pharmacology 616, 73-80 (2009). 5.Pomierny-Chamiolo, L.,Poleszak, E.,Pilc, A., et al. NMDA but not AMPA glutamatergic receptors are involved in the antidepressant-like activity of MTEP during the forced swim test in mice. Pharmacological Reports 62(6), 1186-1190 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 380.2 |
| 分子式 | C12H6N4O6S • 2Na |
| CAS号 | 479347-86-9 |
| 稳定性 | ≥ 2 years |
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