AZ 3146
货号：
19991-50mg 基本售价：
6300.0 元 规格：
50 mg
产品信息
概述| 货号 | 19991-50mg |
| 描述 | AZ 3146 is an inhibitor of the monopolar spindle 1 (Mps1) checkpoint kinase (IC50 = 35 nM).1 It displays selectivity over 46 other kinases including Cdk1 and Aurora kinase B.1 It has been shown to inhibit the recruitment of Mad1, Mad2, and centromere protein E (CENP-E) to kinetochores.1 AZ 3146 can be used with GSK923295 (Item No. 18389), an inhibitor of CENP-E, to generate aneuploidy in cells.2 |
| 别名 | Mps1 Inhibitor III; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lan, W., and Clevelands, D.W. A chemical tool box defines mitotic and interphase roles for Mps1 kinase. J. Cell. Biol. 190(1), 21-24 (2010).
2.Bennett, A.,Bechi, B.,Tighe, A., et al. Cenp-E inhibitor GSK923295: Novel synthetic route and use as a tool to generate aneuploidy. Oncotarget 6(25), 20921-20932 (2015).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 452.6 |
| 分子式 | C24H32N6O3 |
| CAS号 | 1124329-14-1 |
| 稳定性 | ≥ 2 years |
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