Ethacrynic Acid
货号：
19536-10g 基本售价：
6300.0 元 规格：
10 g
产品信息
概述| 货号 | 19536-10g |
| 描述 | Ethacrynic acid is a nonsulfonamide loop diuretic that inhibits the activity of the Na+/K+/2Cl- cotransporter NKCC2 in the thick ascending limb of the loop of Henle.1 It also inhibits glutathione S-transferase and Wnt signaling, producing cytotoxicity in chronic lymphocytic leukemia cells and other tumor cells.2,3 |
| 别名 | MK 595;NSC 85791;NSC 624008; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kunugi, Y.,Hiraoka, Y.,Hashimoto, Y., et al. Ethacrynic acid-sensitive and ATP-dependent Cl- transport in the rat kidney. Japan J.Pharmacol. 57, 167-174 (1991).
2.Lu, D.,Liu, J.X.,Endo, T., et al. Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt/beta-catenin pathway. PLoS One 4(12), e8294 (2009).
3.Liu, B.,Huang, X.,Hu, Y., et al. Ethacrynic acid improves the antitumor effects of irreversible epidermal growth factor receptor tyrosine kinase inhibitors in breast cancer. Oncotarget 7(36), 58038-58050 (2016).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 303.1 |
| 分子式 | C13H12Cl2O4 |
| CAS号 | 58-54-8 |
| 稳定性 | ≥ 2 years |
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