CH5183284
货号：
17120-25mg 基本售价：
6300.0 元 规格：
25 mg
产品信息
概述| 货号 | 17120-25mg |
| 描述 | CH5183284 is a potent, selective inhibitor of the kinase activity of fibroblast growth factor receptors (FGFRs) 1, 2, and 3 (IC50s = 9.3, 7.6, and 22 nM, respectively).1 It less potently inhibits FGFR4 and platelet-derived growth factor receptor β (IC50s = 290 and 560 nM, respectively) and displays IC50 values greater than 1 µM for a diverse panel of tyrosine and serine/threonine kinases.1 CH5183284 is effective against FGFR2 containing the gatekeeper mutation V564F.1 Moreover, it inhibits the growth of cancer cells expressing FGFR genetic alterations both in vitro and in xenograft mouse models.1 |
| 别名 | Debio 1347; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Nakanishi, Y.,Akiyama, N.,Tsukaguchi, T., et al. The fibroblast growth factor receptor genetic status as a potential predictor of the sensitivity to CH5183284/Debio 1347, a novel selective FGFR inhibitor. Molecular Cancer Therapeutics 13(11), 2547-2558 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 356.4 |
| 分子式 | C20H16N6O |
| CAS号 | 1265229-25-1 |
| 稳定性 | ≥ 2 years |
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