Chlorothricin
货号：
15501-5mg 基本售价：
6300.0 元 规格：
5 mg
产品信息
概述| 货号 | 15501-5mg |
| 描述 | Chlorothricin is a macrolide-type antibiotic that inhibits pyruvate carboxylases from Bacillus,Azotobacter, rat, and chicken, preventing the conversion of pyruvate to oxaloacetate (Ki or IC50 = 173, 500, 260, and 120 μM, respectively).1,2 Chlorothricin also inhibits malate dehydrogenases MDH1 (cytoplasmic) and MDH2 (mitochondrial) from pig heart (IC50s = 1.3 and 0.065 mM, respectively), preventing the oxidation of malate to oxaloacetate.3 |
| 别名 | Antibiotic K 818A; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Schindler, P.W. and Zähner, H. Mode of action of the macrolide-type antibiotic, chlorothricin. Kinetic study of the inhibition of pyruvate carboxylase from Bacillus stearothermophilus. European Journal of Biochemistry 39(2), 591-600 (1973).
2.Schindler, P.W. and Scrutton, M.C. Mode of action of the macrolide-type antibiotic, chlorothricin. Effect of the antibiotic on the catalytic activity and some structural parameters of pyruvate carboxylases purified from rat and chicken liver. European Journal of Biochemistry 55(3), 543-553 (1975).
3.Schindler, P.W. Chlorothricin, and inhibitor of porcine-heart malate dehydrogenases, discriminating between the mitochondrial and cytoplasmic isoenzyme. European Journal of Biochemistry 51(2), 579-585 (1975).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 955.5 |
| 分子式 | C50H63ClO16 |
| CAS号 | 34707-92-1 |
| 稳定性 | ≥ 2 years |
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