Exemestane
货号：
15008-50mg 基本售价：
6300.0 元 规格：
50 mg
产品信息
概述| 货号 | 15008-50mg |
| 描述 | Exemestane is a third generation, irreversible steroidal aromatase inhibitor (Ki = 10.2 nM; Kinact = 26 nM) that induces aromatase degradation leading to a decrease in estrogen levels in plasma.1,2 As an androgen analog, exemestane exhibits androgenic effects and has been shown to decrease total and HDL cholesterol, apo A1, and total triglyceride levels.3 Marketed under the trade name Aromasin™, exemestane has been used to treat estrogen receptor-positive breast cancers in post-menopausal women.1 |
| 别名 | Aromasin™;FCE 24304; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Wang, X. and Chen, S. Aromatase destabilizer: Novel action of exemestane, a food and drug administration-approved aromatase inhibitor. Cancer Research 66(21), 10281-10286 (2006).
2.Santen, R.J. and Harvey, H.A. Use of aromatase inhibitors in breast carcinoma. Endocr.-Relat.Cancer 6, 75-92 (1999).
3.Buzdar, A.U.,Robertson, J.F.R.,Eiermann, W., et al. An overview of the pharmacology and pharmacokinetics of the newer generation aromatase inhibitors anastrozole, letrozole, and exemestane. Cancer 95(9), 2006-2016 (2002).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 296.4 |
| 分子式 | C20H24O2 |
| CAS号 | 107868-30-4 |
| 稳定性 | ≥ 2 years |
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