Rocaglamide
货号：
14841-1mg 基本售价：
6300.0 元 规格：
1 mg
产品信息
概述| 货号 | 14841-1mg |
| 描述 | Rocaglamide is an anti-inflammatory, insecticidal, and anticancer tetrahydrobenzofuran isolated from Aglaia species. It has been shown to inhibit both TNF-α and the activation of NF-κB in Jurkat T cells with IC50 values in the nanomolar range.1 At 25 nM, rocaglamide induces apoptosis in various human leukemia cell lines, activating p38 MAPK/JNK and suppressing ERK.2 Rocaglamide also reduces IFN-γ, TNF-α, IL-2, and IL-4 production in peripheral blood T cells at a concentration of 50 nM.3 Furthermore, rocaglamide can inhibit the T cell expression of the immune response transcription factor, nuclear factor of activated T cells.3 |
| 别名 | NSC 326408;Roc-A;Rocaglamide A; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Baumann, B.,Bohnenstengel, F.,Siegmund, D., et al. Rocaglamide derivatives are potent inhibitors of NF-κB activation in T-cells. The Journal of Biological Chemisty 277(47), 44791-44800 (2002).
2.Zhu, J.Y.,Lavrik, I.N.,Mahlknecht, U., et al. The traditional Chinese herbal compound rocaglamide preferentially induces apoptosis in leukemia cells by modulation of mitogen-activated protein kinase activities. International Journal of Cancer 121(8), 1839-1846 (2007).
3.Proksch, P.,Giaisi, M.,Treiber, M.K., et al. Rocaglamide derivatives are immunosuppressive phytochemicals that target NF-AT activity in T cells. Journal of Immunology 174(11), 7075-7084 (2005).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 505.6 |
| 分子式 | C29H31NO7 |
| CAS号 | 84573-16-0 |
| 稳定性 | ≥ 2 years |
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