IDH1 (human recombinant)
货号：
14131-100ug 基本售价：
6300.0 元 规格：
100 ug
产品信息
概述| 货号 | 14131-100ug |
| 描述 | Isocitrate dehydrogenases (IDHs) are NAD+ and NADP+-dependent enzymes that catalyze the third step of the tricarboxylic acid cycle. IDHs catalyze oxidative decarboxylation of isocitrate producing α-ketoglutarate and carbon dioxide. IDH1 (cytosolic) and IDH2 (mitochondrial) are NADP+-dependent enzymes that catalyze reversible reactions. The IDH3 isoform, a NAD+-dependent multisubunit enzyme, is irreversible and allosterically regulated by a variety of positive (calcium, ADP, and citrate) and negative (ATP, NADH, and NADPH) effectors.1 IDH1 and IDH2 are mutated in >70% of lower grade gliomas.2 |
| 别名 | Isocitrate Dehydrogenase (NADP) Cytoplasmic; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Raimundo, N.,Baysal, B.E. and Shadel, G.S. Revisiting the TCA cycle: Signaling to tumor formation. Trends in Molecular Medicine 17(11), 641-649 (2011).
2.Turcan, S.,Rohle, D.,Goenka, A., et al. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature 483(7390), 479-483 (2012).
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| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% estimated by SDS-PAGE |
| 稳定性 | ≥ 6 months |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
