| 货号 | 13266-10mg |
| 描述 | Protein S-palmitoylation is the post-translational acylation of proteins and serves to regulate localization, stability, and interaction with associates and substrates.1 Palmitic acid alkyne is a form of palmitic acid (Item No. 10006627) with an ω-terminal alkyne. The terminal alkyne group can be used in linking reactions, known as click chemistry; this chemistry is characterized by high dependability and specificity of the azide-alkyne bioconjugation reactions.2,3 The use of palmitic acid alkyne and related lipids in isolating palmitoylated proteins has been described.4,5,6 |
| 别名 | Alk-14;Click Tag™ Palmitic Acid Alkyne; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Aicart-Ramos, C.,Valero, R.A., and Rodriguez-Crespo, I. Protein palmitoylation and subcellular trafficking. Biochimica et Biophysica Acta 1808, 2981-2994 (2011). 2.Kolb, H.C., and Sharpless, K.B. The growing impact of click chemistry on drug discovery. Drug Discovery Today 8(24), 1128-1137 (2003). 3.Lutz, J.F., and Zarafshani, Z. Efficient construction of therapeutics, bioconjugates, biomaterials and bioactive surfaces using azide-alkyne "click" chemistry. Advanced Drug Delivery Reviews 60, 958-970 (2008). 4.Martin, B.R., and Cravatt, B.F. Large-scale profiling of protein palmitoylation in mammalian cells. Nature Methods 6(2), 135-138 (2009). 5.Yap, M.C.,Kostiuk, M.A.,Martin, D.D.O., et al. Rapid and selective detection of fatty acylated proteins using ω-alkynyl-fatty acids and click chemistry. Journal of Lipid Research 51, 1566-1580 (2010). 6.Jiang, H.,Khan, S.,Wang, Y., et al. SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine. Nature 496, 110-113 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 252.4 |
| 分子式 | C16H28O2 |
| CAS号 | 99208-90-9 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |