Etifoxine
货号：
15999-50mg 基本售价：
6286.0 元 规格：
50 mg
产品信息
概述| 货号 | 15999-50mg |
| 描述 | Etifoxine is a positive allosteric modulator of GABAA receptors that produces anxiolytic effects by preferentially modulating GABAA receptors containing β2 or β3 subunits (EC50s = 7.5 µM) over those bearing a β1 subunit (EC50 > 20 µM).1 It has also been identified as a ligand of the translocator protein, reportedly reducing inflammatory macrophage activation after peripheral nerve injury (20 µM) and promoting conditions favorable for axon regrowth.2 |
| 别名 | Etafenoxine;HOE 36-801;Stresam; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hamon, A.,Morel, A.,Hue, B., et al. The modulatory effects of the anxiolytic etifoxine on GABAA receptors are mediated by the β subunit. Neuropharmacology 45(3), 293-303 (2003).
2.Girard, C.,Liu, S.,Cadepond, F., et al. Etifoxine improves peripheral nerve regeneration and functional recovery. Proceedings of the National Academy of Sciences of the United States of America 105(51), 20505-20510 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 300.8 |
| 分子式 | C17H17ClN2O |
| CAS号 | 21715-46-8 |
| 稳定性 | ≥ 2 years |
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