N,N-Dimethylsphingosine
货号：
62575-50mg 基本售价：
6272.0 元 规格：
50 mg
产品信息
概述| 货号 | 62575-50mg |
| 描述 | N,N-Dimethylsphingosine is an inhibitor of sphingosine kinase (SPHK). It is a natural metabolite of sphingosine in some cancer cell lines and tissues.1 N,N-Dimethylsphingosine inhibited U937 cell SPHK with a Ki value of 3.1 µM.2 N,N-Dimethylsphingosine induces apoptosis, but it is not an inhibitor of protein kinase C. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Yatomi, Y.,Ruan, F.,Megidish, T., et al. N,N-Dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets. Biochemistry 35, 626-633 (1996).
2.Edsall, L.C.,Van Brocklyn, J.R.,Cuvillier, O., et al. N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: Modulation of cellular levels of sphingosine 1-phosphate and ceramide. Biochemistry 37, 12892-12898 (1998).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 327.6 |
| 分子式 | C20H41NO2 |
| CAS号 | 119567-63-4 |
| 稳定性 | ≥ 1 year |
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