| 货号 | 11576-10g |
| 描述 | Sodium-glucose cotransporter 1 (SGLT1) is a high affinity, low capacity transporter abundant in the small intestine, with some expression in the kidney as well. SGLT2 is a low affinity, high capacity transporter in the kidney that accounts for approximately 90% of glucose reabsorption into the blood stream. Selective inhibition of SGLT2 is a potential strategy for reducing plasma glucose levels as a treatment for diabetes.1 Phlorizin is a natural product, first isolated from the bark of apple trees, that reduces plasma glucose levels by blocking renal and intestinal glucose absorption through inhibition of SGLT1 and SGLT2.2,3 It competitively inhibits the initial rate of α-methyl-D-glucopyranoside (α-MDG) uptake in human COS-1 cells expressing hSGLT1 and hSGLT2 with IC50 values of 400 and 65 nM, respectively.4 In HEK293T cells expressing human SGLT1 and SGLT2, phlorizin exhibits Ki values of 140 and 11 nM, respectively, at 37°C.4,5 |
| 别名 | Floridzin;NSC 2833; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Chao, E.C., and Henry, R.R. SGLT2 inhibition - A novel strategy for diabetes treatment. Nature Reviews.Drug Discovery 9(7), 551-559 (2010). 2.White, J.R., Jr. Apple trees to sodium glucose co-transporter inhibitors: A review of SGLT2 inhibition. Clinical Diabetes 28(1), 5-10 (2010). 3.Ehrenkranz, J.R.L.,Lewis, N.G.,Kahn, C.R., et al. Phlorizin: A review. Diabetes/Metabolism Research and Reviews 21, 31-38 (2005). 4.Hummel, C.S.,Lu, C.,Liu, J., et al. Structural selectivity of human SGLT inhibitors. American Journal of Physiology.Cell Physiology 302(2), C373-C382 (2012). 5.Hummel, C.S.,Lu, C.,Loo, D.D.F., et al. Glucose transport by human renal Na+/D-glucose cotransporters SGLT1 and SGLT2. American Journal of Physiology.Cell Physiology 300, C14-C21 (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 436.4 |
| 分子式 | C21H24O10 |
| CAS号 | 60-81-1 |
| 稳定性 | ≥ 2 years |
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