Icilin
货号：
10137-100mg 基本售价：
6272.0 元 规格：
100 mg
产品信息
概述| 货号 | 10137-100mg |
| 描述 | Nociceptive sensory peripheral neurons often express both heat sensitive (VR1) and cold-sensitive (CMR1 (rat); TRPM8 (human)) receptors that are part of the transient receptor potential (TRP) superfamily. Icilin (AG 3-5) is a synthetic CMR1/TRPM8 super agonist that is 2.5-fold more efficacious and nearly 200-fold more potent than the reference cold thermosensory agonist, l-menthol.1 Icilin induces sensations of intense cold when applied orally in humans, and induces wet dog shakes, a behavioral marker of cold sensation, when given to rats. Icilin should serve as the reference cold nociceptive agonist for TRP-type ion channels in the future.2 |
| 别名 | AG 3-5; |
性能| 供应商 | Cayman |
| 应用文献 |
1.McKemy, D.D.,Neuhausser, W.M., and Julius, D. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 416, 52-58 (2002).
2.Wei, E.T., and Seid, D.A. AG-3-5: A chemical producing sensations of cold. Journal of Pharmacy and Pharmacology 35, 110-112 (1983).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 311.3 |
| 分子式 | C16H13N3O4 |
| CAS号 | 36945-98-9 |
| 稳定性 | ≥ 2 years |
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