DDMS
货号：
10018-10mg 基本售价：
6272.0 元 规格：
10 mg
产品信息
概述| 货号 | 10018-10mg |
| 描述 | Biosynthesis of 20-HETE from arachidonic acid by the cytochrome P450 4A (CYP450 4A) isoforms is an important component of vascular homeostasis, especially in renal circulation.1 DDMS is a mechanism-based, irreversible inhibitor that has about 10-fold selectivity for the CYP4A2 enzyme which predominantly synthesizes 20-HETE in the mammalian kidney. DDMS administration in whole anesthetized rats (10 mg/kg) largely ablates the hypotension and vasodilation induced by nitric oxide donors such as NONOates.2 |
| 别名 | Dibromo-dodecenyl-methylsulfimide; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lasker, J.M.,Chen, W.B.,Wolf, I., et al. Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of CYP4F2 and CYP4A11. The Journal of Biological Chemisty 275(6), 4118-4126 (2000).
2.Alonso-Galicia, M.,Drummond, H.A.,Reddy, K.K., et al. Inhibition of 20-HETE production contributes to the vascular responses to nitric oxide. Hypertension 29, 320-325 (1997).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 433.2 |
| 分子式 | C13H23Br2NO3S |
| CAS号 | 206052-03-1 |
| 稳定性 | ≥ 2 years |
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