| 货号 | 21683-5mg |
| 描述 | Complement 3a (C3a) receptor agonist binds the G protein-coupled C3a receptors (C3aRs) in the immune system complement pathway.1 Activation of C3aR prevents neutrophils from being mobilized in a model of intestinal ischemia-reperfusion injury.2 C3aRs are expressed on neural progenitor cells and immature neurons in adult mice. C3a stimulates differentiation of neural progenitor cells in vitro.3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Klos, A.,Wende, E.,Wareham, K.J., et al. International union of basic and clinical pharmacology. LXXXVII. Complement peptide C5a, C4a, and C3a receptors. Pharmacol. Rev. 65(1), 500-543 (2013). 2.Wu, M.C.L.,Brennan, F.H.,Lynch, J.P.L., et al. The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilization. Proc. Natl. Acad. Sci. USA 110923), 9439-9444 (2013). 3.Rahpaymai, Y.,Hietala, M.A.,Wilhelmsson, U., et al. Complement: A novel factor in basal and ischemia-induced neurogenesis. EMBO J. 25(6), 1364-1374 (2006). 4.Shinjyo, N.,Ståhlberg, A.,Dragunow, M., et al. Complement-derived anaphylatoxin C3a regulates in vitro differentiation and migration of neural progenitor cells. Stem Cells 27(11), 2824-2832 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 433.6 |
| 分子式 | C27H35N3O2 |
| CAS号 | 944997-60-8 |
| 稳定性 | ≥ 2 years |
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