Narasin (sodium salt)
货号：
19447-25mg 基本售价：
6244.0 元 规格：
25 mg
产品信息
概述| 货号 | 19447-25mg |
| 描述 | Narasin is an ionophore antibiotic isolated from certain Streptomyces sp. and used in veterinary practice as a coccidiostat for gastrointestinal parasites. It has also been shown to inhibit NF-κB signaling via inhibition of IκBα phosphorylation (IC50 = 3.2 µM) and to stimulate tumor necrosis factor-related apoptosis-induced ligand (TRAIL)-mediated apoptosis in glioma cells via ER stress.1,2 |
| 别名 | 4-Methylsalinomycin;Monteban;Narasin A; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Miller, S.C.,Huang, R.,Sakamuru, S., et al. Identification of known drugs that act as inhibitors of NF-κB signaling and their mechanism of action. Biochem. Pharmacol. 79(9), 1272-1280 (2016).
2.Yoon, M.J., and Kang, Y.J. Monensin, a polyether ionophore antibiotic, overcomes TRAIL resistance in glioma cells via endoplasmic reticulum stress, DR5 upregulation and c-FLIP downregulation. Carcinogenesis 34(8), 1918-1928 (2013).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 787 |
| 分子式 | C43H71O11 • Na |
| CAS号 | 58331-17-2 |
| 稳定性 | ≥ 2 years |
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