Ivermectin B1a
货号：
18768-25mg 基本售价：
6244.0 元 规格：
25 mg
产品信息
概述| 货号 | 18768-25mg |
| 描述 | Ivermectin B1a is the main component (>80%) of the anthelmintic, ivermectin.1 It produces antiparasitic activity by binding to glutamate-gated chloride channels expressed on nematode neurons and pharyngeal muscle cells, inducing irreversible channel opening and very long-lasting hyperpolarization/depolarization of the neuron/muscle cell, thereby blocking further function (EC50 = 104 nM).2,3 |
| 别名 | dihydro Avermectin B1a;22,23-dihydro Avermectin B1a; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Gaisser, S.,Kellenberger, L.,Kaja, A.L., et al. Direct production of ivermectin-like drugs after domain exchange in the avermectin polyketide synthase of Streptomyces avermitilis ATCC31272. Organic & Biomolecular Chemistry 1(16), 2840-2847 (2003).
2.Wolsetnholme, A.J., and Rogers, A.T. Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics. Parasitology 131 Suppl, S85-S95 (2005).
3.Arena, J.P.,Liu, K.K.,Paress, P.S., et al. The mechanism of action of avermectins in Caenorhabditis elegans: Correlation between activation of glutamate-sensitive chloride current, membrane binding, and biological activity. Journal of Parasitology 81, 286-294 (1995).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 875.1 |
| 分子式 | C48H74O14 |
| CAS号 | 71827-03-7 |
| 稳定性 | ≥ 2 years |
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