| 货号 | 6007/50 |
| 别名 | 4-Amino-N'-(3-chloro-4-fluorophenyl) |
| 供应商 | Tocris |
| 生物活性 | Potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50 values are 19 and 67 nM in enzymatic activity and HeLa cell assays, respectively). Decreases kynurenine levels in plasma and reduces tumor growth in vivo. Cell membrane permeable. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 271.64 |
| 分子式 | C9H7ClFN5O2< |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Weinmann (2016) Cancer immunotherapy: selected targets and small-molecule modulators. Chem.Med.Chem. 11 450. PMID: 26836578. Dounayet al (2015) Challenges and opportunities in the discovery of new therapeutics targeting the kynurenine pathway. J.Med.Chem. 58 8762. PMID: 26207924. Yueet al (2009) Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model. J.Med.Chem. 52 7364. PMID: 19507862. |