| 货号 | 5425/50 |
| 别名 | N-1,3,4-Thiadiazol-2-yl-3-pyridinec |
| 供应商 | Tocris |
| 生物活性 | Aquaporin 4 (AQP4) channel blocker (IC50 = 3.1 μM). Increases regional cerebral blood flow and reduces ischemia-induced brain edema in mice. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 206.22 |
| 分子式 | C8H6N4OS |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO and to 10 mM in 1eq. HCl with gentle warming |
| 参考文献 | Igarashiet al (2013) Inhibition of aquaporin-4 significantly increases regional cerebral blood flow. Neuroreport 24 324. PMID: 23462267. Igarashi and Huber (2011) Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema. Neurol.Sci. 32 113. PMID: 20924629. Huberet al (2009) Identification of aquaporin 4 inhibitors using in vitroandin silico methods. Bioorg.Med.Chem. 17 411. PMID: 18182301. |