| 货号 | 1225/50 |
| 别名 | 1,4-Bis(3,5-Dichloro-2-pyridinyloxy |
| 供应商 | Tocris |
| 生物活性 | Agonist of the constitutive androstane receptor (CAR) (EC50 = 20 nM). Induces activity of ER1 cytochrome P450 isozymes, NADPH-cytochrome c reductase, microsomal epoxide hydrolase and glutathione S transferase. Potent mitogen; induces liver cell proliferation in mice. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 402.06 |
| 分子式 | C16H8Cl4N2 |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO |
| 参考文献 | Tzameliet al (2000) The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR. Mol.Cell.Biol. 20 2951. PMID: 10757780. Ledda-Columbanoet al(1998)In vivo hepatocyte proliferation is inducible through a TNF and IL-6-independent pathway. Oncogene 17 1039. PMID: 9747883. Polandet al (1980) 1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene, a potent phenobarbital-like inducer of microsomal monooxygenase activity. Mol.Pharmacol. 18 571. PMID: 7464820. |