| 货号 | 0923/50 |
| 别名 | N-(Piperidin-1-yl)-5-(4-chloropheny |
| 供应商 | Tocris |
| 生物活性 | Potent and selective cannabinoid CB1 receptor antagonist (Ki= 1.98 nM). Also acts as an inverse agonist reversing adenylyl cyclase inhibition by WIN 55,212-2 (Cat.No. 1038) (IC50 = 48 nM). Displays no activity at CB2 receptors. Reduces food intake and body weight in orally dosed non-obese Wistar rats. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 500.25 |
| 分子式 | C22H21Cl3N4< |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Janiaket al (2007) Blockade of cannabinoid CB1 receptors improves renal function, metabolic profile, and increased survival of obese Zucker rats. Kidney Int. 72 1345. PMID: 17882151. Colomboet al (1998) Appetite suppression and weight loss after the cannabinoid antagonist SR 141716. Life Sci. 63 113. PMID: 9718088. Rinaldi-Carmonaet al (1995) Biochemical and pharmacological characterisation of SR 141716A, the first potent and selective brain cannabinoid receptor antagonist. Life Sci. 56 1941. PMID: 7776817. Rinaldi-Carmonaet al (1994) SR 141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Lett. 350 240. PMID: 8070571. |