| 货号 | 1586/50 |
| 别名 | 8-Bromo-2,3,4,5-tetrahydro-3-methyl |
| 供应商 | Tocris |
| 生物活性 | Potent and selective D1-like dopamine receptor antagonist (Ki~ 0.56 nM for D1; KB = 2 μM for D2). Also antagonist at the vascular 5-HT2 receptor (Ki = 11 nM). Displays selective inhibition of adenylyl cyclase 2 (AC2); inactive against AC1 or AC5. Centrally active following systemic administration in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 413.15 |
| 分子式 | C17H18BrNO.HBr |
| 可溶性/溶解性 | Soluble to 5 mM in water with gentle warming and to 100 mM in DMSO |
| CAS号 | 99295-33-7 |
| 参考文献 | Conleyet al (2013) Development of a high-throughput screening paradigm for the discovery of small-molecule modulators of adenylyl cyclase: identification of an adenylyl cyclase 2 inhibitor. J.Pharmacol.Exp.Ther. 347 276. PMID: 24008337. Frittset al (1998) Locomotor stereotypy produced by dexbenzetimide and scopolamine is reduced by SKF 83566, not sulpiride. Pharmacol.Biochem.Behav. 60 639. PMID: 9678647. Meyeret al (1993) Effects of dopamine D1 antagonists SCH23390 and SK&F83566 on locomotor activities in rats. Pharmacol.Biochem.Behav. 44 429. PMID: 8446676. Ohlstein and Berkowitz (1985) SCH 23390 and SK&F 83566 are antagonists at vascular dopamine and serotonin receptors. Eur.J.Pharmacol. 108 205. PMID: 3884345. |