| 货号 | 4292/50 |
| 别名 | N-[[4-[(6-Chloro-3-pyridinyl)methox |
| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of PLK1 (IC50 values are 200 pM, 875 nM and 66 μM for PLK1, PLK3 and PLK2 respectively). Exhibits no effect on Aurora kinase A activity. Binds and stabilizes the inactive form of PLK1. Delays cell cycle progression, reduces cell proliferation and induces apoptosis in a range of human cancer cell lines. Transiently arrests cells cycle at G0/G1 in primary cells. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 479.4 |
| 分子式 | C24H27ClN2O4 |
| 可溶性/溶解性 | Soluble to 10 mM in water with gentle warming and to 100 mM in DMSO |
| 参考文献 | Keppneret al (2011) Fate of primary cells at the G1/S boundary after Polo-like kinase 1 inhibition by SBE13. Cell Cycle 10 708. PMID: 21301227. Eckerdt (2010) Freezing Polo in its sleep: targeting the inactive conformation of Polo-like kinase 1 in cancer cells. Cell Cycle 9 (5) 862. PMID: 20348843. Keppneret al (2010) Biological impact of freezing Plk1 in its inactive conformation in cancer cells. Cell Cycle 9 761. PMID: 20139717. Liu (2010) SBE13 joins the family of Polo-like kinase 1 (Plk1) inhibitors. Cell Cycle 9 445. PMID: 20130451. Keppneret al (2009) Identification and validation of a potent type II inhibitor of inactive polo-like kinase 1. ChemMedChem 4 1806. PMID: 19746360. |