| 货号 | 4348/50 |
| 别名 | (Diphenylacetyl)-carbamic acid ethy ester |
| 供应商 | Tocris |
| 生物活性 | Positive allosteric modulator of mGlu1 receptors. Potentiates glutamate-induced calcium release (EC50 = 104.2 nM at rat mGluR1a). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 283.32 |
| 分子式 | C17H17NO3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Brocket al (2007) Activation of a dimeric metabotropic glutamate receptor by intersubunit rearrangement. J.Biol.Chem. 282 33000. PMID: 17855348. Hemstapatet al (2006) A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators. Mol.Pharmacol. 70 616. PMID: 16645124. Knoflachet al (2001) Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site. Proc.Natl.Acad.Sci.USA 98 13402. PMID: 11606768. |