| 货号 | 3554/1 |
| 供应商 | Tocris |
| 生物活性 | Cell-permeable peptide cleaved from protease-activated receptor 1 (PAR1) upon receptor activation. Attenuates endothelial cell migration and proliferation (IC50 ~ 20 μM), and induces cell cycle arrest. Promotes activation of caspase-3 and exhibits pro-apoptotic activity in vitro. Inhibits angiogenesis and exhibits cardioprotective activity in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 4419.19 |
| 分子式 | C189H326N58O57S3 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| CAS号 | 1065756-01-5 |
| 序列号 | MGPRRLLIVALGLSLCGPLLSSRVPMSQPE |
| 参考文献 | Strandeet al (2009) Parstatin: a cryptic peptide involved in cardioprotection after ischaemic and reperfusion injury. Cardiovasc.Res. 83 325. PMID: 19380418. Zaniaet al (2009) Parstatin, the cleaved peptide on proteinase-activated receptor 1 activation, is a potent inhibitor of activation. J.Pharmacol.Exp.Ther. 328 378. PMID: 18988770. |