NS 19504 (50 MG)
货号：
5276/50 基本售价：
6236.2 元 规格：
50 mg
产品信息
概述| 货号 | 5276/50 |
| 别名 | 5-[(4-Bromophenyl)methyl]-2-thiazolamine |
性能| 供应商 | Tocris |
| 生物活性 | Selective activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1) (EC50 = 11 μM). Activates BK channels in native smooth muscle cells from guinea pig bladder and reduces spontaneous phasic contractions in bladder strips ex vivo. Displays no effect on contractions induced by a high K+ concentration or at 65 other receptors tested, including L- and N- type Ca2+ channels, Nav, KATP and hERG channels. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 269.16 |
| 分子式 | C10H9BrN2S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| 参考文献 | Nauschet al (2014) NS19504: a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions. J.Pharmacol.Exp.Ther. 350 520. PMID: 24951278. |
