| 货号 | 3499/50 |
| 别名 | 4-Amino-5-chloro-2-methoxybenzoic acid 2-(1-piperidinyl)ethyl ester hydrochloride |
| 供应商 | Tocris |
| 生物活性 | Potent 5-HT4 partial agonist (EC50 = 4 nM) that displays > 680-fold selectivity over 5-HT3 receptors (Ki values are 1.07 and 730 nM respectively). Increases sAPPα levels in the cortex in an animal model of Alzheimer's disease and exhibits progastrokinetic effects in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 349.25 |
| 分子式 | C15H21CIN2O3.HCl |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO and to 20 mM in ethanol |
| CAS号 | 148868-55-7 |
| 参考文献 | Cachard-Chastelet al (2007) 5-HT4 receptor agonists increase sAPPα levels in the cortex and hippocampus of male C57BL/6j mice. Br.J.Pharmacol. 150 883. PMID: 17325649. Pontiet al (2001) Intestinal motor stimulation by the 5-HT4 receptor agonist ML10302: differential involvement of tachykininergic pathways in the canine small bowel and colon. Neurogastroenterol.Mot. 13543. Yanget al (1997) New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors. J.Med.Chem. 40 608. PMID: 9046352. |