| 货号 | 0504/50 |
| 别名 | [1,1'-Biphenyl]-2,2'-diyliodonium chloride; DPI |
| 供应商 | Tocris |
| 生物活性 | GPR3 agonist (EC50 = 1 μM); activates adenylate cyclase through GPR3 but not GPR6 or GPR12. Also induces Ca2+ mobilization and β-arrestin receptor internalization. Binds strongly to flavoproteins; inhibits several enzymes, including NO synthase, NADPH oxidases and NADPH cytochrome P450 oxidoreductase. Also inhibits platelet aggregation. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 314.55 |
| 分子式 | C12H8ClI |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO |
| CAS号 | 244-54-2 |
| 参考文献 | Yeet al (2014) Identification of a novel small-molecule agonist for human G protein-coupled receptor 3. J.Pharmacol.Exp.Ther. 349 437. PMID: 24633425. Tew (1993) Inhibition of cytochrome P450 reductase by the diphenyliodonium cation. Kinetic analysis and covalent modifications. Biochemistry 32 10209. PMID: 8399148. Wanget al (1993) Inhibitory actions of diphenyleneiodonium dependent vasodilations in vitroandin vivo. Br.J.Pharmacol. 110 1232. PMID: 7507779. Stuehret al (1991) Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs. FASEB J. 5 98. PMID: 1703974. Yeaet al (1990) Purification and some properties of the 45 kDa diphenylene iodonium-binding flavoprotein of neutrophil NADPH oxidase. Biochem.J. 265 95. PMID: 2154184. |