| 货号 | 4568/50 |
| 别名 | 4-[3-(2-Chlorophenyl)-2-propen-1-yl |
| 供应商 | Tocris |
| 生物活性 | DOCK2-Rac1 interaction inhibitor; suppresses DOCK2-induced Rac1 activation. Also inhibits DOCK1 and DOCK5. Exhibits selectivity over DOCK9. Reduces chemotactic responses in vitroandin vivo, and activates T cells in vitro. Also attenuates HER2-mediated breast cancer cell migration in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 324.76 |
| 分子式 | C18H13ClN2O2 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Laurinet al (2013) Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis. Proc.Natl.Acad.Sci.U.S.A. 110 7434. PMID: 23592719. Nishikimiet al (2012) Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2. Chem.Biol. 19 488. PMID: 22520755. |