| 货号 | 5233/50 |
| 别名 | N-[2-[(4-Chlorophenyl)amino]-1-meth |
| 供应商 | Tocris |
| 生物活性 | Rho/SRF pathway inhibitor; stimulates apoptosis of a melanoma cell line overexpressing RhoC (A375M2). Suppresses Rho-dependent invasion of PC-3 prostate cancer cells in vitro and inhibits lysophosphatidic acid-induced DNA synthesis in PC-3 prostate cancer cells. When used in combination with Retinoic acid, LY 294002 and Pyridone 6, it induces intermediate mesoderm differentiation from ESCs. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 454.75 |
| 分子式 | C18H13ClF6N2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Maeet al (2010) Combination of small molecules enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells. Biochem.Biophys.Res.Commun. 393 877. PMID: 20171952. Evelynet al (2007) CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling. Mol.Cancer Ther. 6 2249. PMID: 17699722. |