| 货号 | 2427/1 |
| 供应商 | Tocris |
| 生物活性 | Endogenous APJ receptor agonist that is secreted by adipocytes. Binds with high affinity to APJ receptors (IC50 = 5.4 nM) and potently inhibits cAMP production in vitro(EC50 = 0.52 nM). Involved in regulation of cardiovascular function, fluid homeostasis and feeding. Blocks entry of some HIV-1 and HIV-2 strains into NP-2/CD4 cells expressing APJ. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 4200.93 |
| 分子式 | C185H304N68O43S |
| 可溶性/溶解性 | Soluble to 1.60 mg/ml in water |
| CAS号 | 230299-95-3 |
| 序列号 | LVKPRTSRTGPGAWQGGRRKFRRQRPRLSH |
| 参考文献 | Kawamataet al (2001) Molecular properties of apelin: tissue distribution and receptor binding. Biochim.Biophys.Acta 1538 162. PMID: 11336787. Zouet al (2000) Apelin peptides block the entry of human immunodeficiency virus (HIV). FEBS Lett. 473 15. PMID: 10802050. Tatemotoet al (1998) Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem.Biophys.Res.Comm. 251471. |