| 货号 | 2426/1 |
| 供应商 | Tocris |
| 生物活性 | Endogenous APJ receptor agonist (EC50 = 20 nM) that is secreted by adipocytes. Binds with high affinity to human APJ receptors expressed in HEK 293 cells (pIC50= 8.61). Involved in regulation of cardiovascular function, fluid homeostasis and feeding. Blocks entry of some HIV-1 and HIV-2 strains into NP-2/CD4 cells expressing APJ. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 4195.87 |
| 分子式 | C184H297N69O43S |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| CAS号 | 252642-12-9 |
| 序列号 | LVQPRGSRNGPGPWQGGRRKFRRQRPRLSH |
| 参考文献 | Medhurstet al (2003) Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. J.Neurochem. 84 1162. PMID: 12603839. Zouet al (2000) Apelin peptides block the entry of human immunodeficiency virus (HIV). FEBS Lett. 473 15. PMID: 10802050. Tatemotoet al (1998) Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem.Biophys.Res.Comm. 251471. |