| 货号 | 1807/50 |
| 别名 | (17β)-2-Methoxyestra-1,3,5(10)-trien |
| 供应商 | Tocris |
| 生物活性 | Apoptotic, antiproliferative and antiangiogenic agent, in vitroandin vivo; acts via an estrogen receptor-independent mechanism. Induces p53-induced apoptosis via two pathways: activation of p38 and NF-κB; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation. Also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 302.41 |
| 分子式 | C19H26O3 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| CAS号 | 362-07-2 |
| 参考文献 | LaValleeet al (2003) 2-Methoxyestradiol up-regulates death receptor 5 and induces apoptosis through activation of the extrinsic pathway. Cancer Res. 63 468. PMID: 12543804. Shimadaet al (2003) Roles of p38 and c-jun NH2-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis. Carcinogenesis 24 1067. PMID: 12807754. LaValleeet al (2002) 2-Methoxyestradiol inhibits proliferation and induces apoptosis independently of estrogen receptors α and β. Cancer Res. 62 3691. PMID: 12097276. D'Amatoet al (1994) 2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site. Proc.Natl.Acad.Sci.U.S.A. 91 3964. PMID: 8171020. |