Antalarmin (hydrochloride)
货号：
15147-50mg 基本售价：
6230.0 元 规格：
50 mg
产品信息
概述| 货号 | 15147-50mg |
| 描述 | Corticotropin-releasing hormone (CRH) secreted from the hypothalamus is the major regulator of pituitary corticotropin-release and consequent glucocorticoid secretion. Antalarmin is a selective, nonpeptide antagonist of the CRH receptor 1 (Ki = 1 nM) that, consequently, reduces the release of corticotropin in response to chronic stress.1 Through its antagonism of central CRH signaling, antalarmin can reduce endocrinological, cardiovascular, and behavioral responses to stressful stimuli.2 It has also been shown to reduce dose escalation in cocaine-addicted rats, to produce anti-inflammatory effects in arthritis models, and to suppress stress-induced gastric ulceration related to irritable bowel syndrome.3,2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Webster, E.L.,Lewis, D.B.,Torpy, D.J., et al. In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: Suppression of pituitary ACTH release and peripheral inflammation. Endocrinology 137, 5747-5750 (1996).
2.Deak, T.,Nguyen, K.T.,Ehrlich, A.L., et al. The impact of the nonpeptide corticotropin-releasing hormone antagonist antalarmin on behavioral and endocrine responses to stress. Endocrinology 140(1), 79-86 (1999).
3.Fahmy, H.,Spyridaki, K.,Kuppast, B., et al. The "homeostasis hormone" and its CRF1 receptor. From structure to function. Hormones (Athens) 11(3), 254-271 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 415 |
| 分子式 | C24H34N4 • HCl |
| CAS号 | 220953-69-5 |
| 稳定性 | ≥ 2 years |
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