| 货号 | 21803-10mg |
| 描述 | MK-0812 is a potent C-C chemokine receptor type 2 (CCR2) antagonist (IC50 = 5 nM for human CCR2).1 In a mouse model of antibody-induced arthritis, MK-0812 did not affect disease severity.2 Clinical trials for the use of MK-0812 for rheumatoid arthritis and multiple sclerosis were terminated early due to a lack of efficacy.3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Abagyan, R.,Christopoulos, A.,de Esch, I.J.P., et al. Chemokines and their receptors in drug discovery. Chemokines. Chemokines and their receptors in drug discovery 1-248 (2015). 2.Min, S.-H.,Wang, Y.,Gonsiorek, W., et al. Pharmacological targeting reveals distinct roles for CXCR2/CXCR1 and CCR2 in a mouse model of arthritis. Biochem. Biophys. Res. Commun. 391(1), 1080-1086 (2010). 3.Zhao, Q. Dual targeting of CCR2 and CCR5: Therapeutic potential for immunologic and cardiovascular diseases. J. Leukoc. Biol. 88(1), 41-55 (2010). 4.Horuk, R. Chemokine receptor antagonists: Overcoming developmental hurdles. Nat. Rev. Drug Discov. 8(1), 23-33 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 469.5 |
| 分子式 | C24H34F3N3O3 |
| CAS号 | 624733-88-6 |
| 稳定性 | ≥ 2 years |
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