| 货号 | 18224-5mg |
| 描述 | Estradiol 3-sulfate is a sulfated form of the steroid hormone 17β-estradiol (Item No. 10006315), and is common in fetal plasma and in the breast tissues of patients with mammary carcinoma.1,2,3 Sulfated estrogens, including estradiol 3-sulfate, can be converted back to the parent compound by sulfatases.3,4 Estradiol 3-sulfate 17β-glucuronide is a metabolite of estradiol 3-sulfate that has been modified by a UDP-glucuronosyltransferase. Glucuronidation of estrogens enhances their utilization by anion transporters, most commonly leading to excretion in urine and bile.3,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Winikor, J.,Schlaerth, C.,Rabaglino, M.B., et al. Complex actions of estradiol-3-sulfate in late gestation fetal brain. Reprod.Sci. 18(7), 654-665 (2011). 2.Pasqualini, J.R.,Gelly, C.,Nguyen, B.L., et al. Importance of estrogen sulfates in breast cancer. Journal of Steroid Biochemistry 34(1-6), 155-163 (1989). 3.Raftogianis, R.,Creveling, C.,Weinshilboum, R., et al. Chapter 6: Estrogen metabolism by conjugation. J.Natl.Cancer Inst.Monogr. 27, 113-124 (2000). 4.Mueller, J.W.,Gilligan, L.C.,Idkowiak, J., et al. The regulation of steroid action by sulfation and desulfation. Endocrine Reviews er20151036, (2015). 5.Loe, D.W.,Almquist, K.C.,Cole, S.P., et al. ATP-dependent 17β-estradiol 17-(β-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids. The Journal of Biological Chemisty 271(16), 9683-9689 (1996). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 604.8 |
| 分子式 | C24H30O11S • 2K |
| CAS号 | 10392-35-5 |
| 稳定性 | ≥ 2 years |
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