| 货号 | 19078-5mg |
| 描述 | Mycophenolic acid β-D-glucuronide (MPAG) is the primary metabolite of the antibiotic mycophenolic acid, a potent inhibitor of inosine monophosphate dehydrogenase.1 Inhibition of this enzyme blocks de novo GTP generation as well as RNA and DNA synthesis in lymphocytes, thus preventing lymphocyte proliferation and activation.1 Mycophenolic acid, typically used in clinical settings as a chemotherapeutic or immunosuppressant agent, is rapidly conjugated on adsorption and circulates mostly in the form of its glucuronide conjugate.1,2,3 At 6 mg/mouse/day, MPAG has been reported to show significant antitumor activity against Ehrlich solid tumors.4 This glucuronide is typically used as an internal standard for therapeutic drug monitoring analyses of serum or whole blood by HPLC or LC-MS to confirm that patients remain within the drug’s therapeutic range.5 |
| 别名 | MPAG;Mycophenolic Acid Glucosiduronate; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Watkins, W.J.,Chen, J.M.,Cho, A., et al. Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDH. Bioorganic & Medicinal Chemistry Letters 16(13), 3479-3483 (2006). 2.Encke, J.,Uhl, W.,Stremmel, W., et al. Immunosuppression and modulation in liver transplantation. Nephrology Dialysis Transplantation 19(Suppl. 4), iv22-iv25 (2004). 3.Knoop, C.,Haverich, A., and Fischer, S. Immunosuppressive therapy after human lung transplantation. European Respiratory Journal 23, 159-171 (2004). 4.Ando, K.,Suzuki, S., and Arita, M. Synthesis of mycophenolic acidβD-glucuronide and its antitumor activity. J.Antibiot.(Tokyo) 23(8), 408-413 (1970). 5.Sobiak, J.,Resztak, M.,Ostalska-Nowicka, D., et al. Monitoring of mycophenolate mofetil metabolites in children with nephrotic syndrome and the proposed novel target values of pharmacokinetic parameters. European Journal of Pharmaceutical Sciences 77, 189-196 (2015). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 496.5 |
| 分子式 | C23H28O12 |
| CAS号 | 31528-44-6 |
| 稳定性 | ≥ 2 years |
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