Calphostin C
货号：
15383-500ug 基本售价：
6174.0 元 规格：
500 ug
产品信息
概述| 货号 | 15383-500ug |
| 描述 | Calphostin C is a metabolite of the fungus C. cladosporioides that specifically inhibits protein kinase C (PKC) (IC50 = 50 nM versus an IC50 > 50 μM for PKA) by competing at the binding site for diacylglycerol and phorbol esters.1 As a polycyclic hydrocarbon with strong absorbance in the visible and ultraviolet ranges, activation of this compound is strictly dependent on exposure to light.2 Independent of PKC, calphostin C also directly inhibits phospholipase D1 and D2(IC50s = 100 nM).3 It demonstrates antitumor activity, inhibiting cell growth and promoting apoptosis in HeLa S3 and MCF-7 cells with IC50 values of 0.23 and 0.18 μM, respectively.1 |
| 别名 | Cladochrome E;PKF 115-584;UCN 1028C; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kobayashi, E.,Ando, K.,Nakano, H., et al. Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities. J.Antibiot.(Tokyo) 42(10), 1470-1474 (1989).
2.Bruns, R.F.,Miller, F.D.,Merriman, R.L., et al. Inhibition of protein kinase C by calphostin C is light-dependent. Biochemical and Biophysical Research Communications 176(1), 288-293 (1991).
3.Sciorra, V.A.,Hammond, S.M. and Morris, A.J. Potent direct inhibition of mammalian phospholipase D isoenzymes by calphostin-c. Biochemistry 40(8), 2640-2646 (2001).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 790.8 |
| 分子式 | C44H38O14 |
| CAS号 | 121263-19-2 |
| 稳定性 | ≥ 2 years |
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