Torin 1
货号：
10997-50mg 基本售价：
6174.0 元 规格：
50 mg
产品信息
概述| 货号 | 10997-50mg |
| 描述 | Torin 1 is a potent and selective inhibitor of mTOR (IC50 = 2 and 10 nM for mTORC1 and mTORC2, respectively).1,2 It shows over 100-fold selectivity for mTOR over PI3Kα and other PI3K-like kinases, including ATM, DNA-PK, and hVps34, as well as 450 other protein kinases.1,2 Torin 1, is efficacious at a dose of 20 mg/kg in inhibiting downstream effectors of mTOR in mice.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Thoreen, C.C.,Kang, S.A.,Chang, J.W., et al. An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. The Journal of Biological Chemisty 284(12), 8023-8032 (2009).
2.Liu, Q.,Chang, W.,Wang, J., et al. Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer. J.Med.Chem 53(19), 7146-7155 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 607.6 |
| 分子式 | C35H28F3N5O2 |
| CAS号 | 1222998-36-8 |
| 稳定性 | ≥ 2 years |
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