| 货号 | 10009984-50ug |
| 描述 | (±)5(6)-EET-d11 contains 11 deuterium atoms at the 16, 16, 17, 17, 18, 18 ,19, 19 ,20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of (±)5(6)-EET (Item No. 50211) by GC- or LC-mass spectrometry (MS). (±)5(6)-EET is biosynthesized in rat and rabbit liver microsomes by cCYP450.1,2 In neuroendocrine cells, such as the anterior pituitary and pancreatic islet, (±)5(6)-EET has been implicated in the mobilization of Ca2+ and hormone secretion.3,4 |
| 别名 | (±)5(6)-EpETrE-d11; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Chacos, N.,Falck, J.R.,Wixtrom, C., et al. Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid. Biochemical and Biophysical Research Communications 104, 916-922 (1982). 2.Oliw, E.H.,Guengerich, F.P., and Oates, J.A. Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. The Journal of Biological Chemisty 257, 3771-3781 (1982). 3.Snyder, C.,Lattanzio, F.,Yadagiri, P., et al. 5,6-Epoxyeicosatrienoic acid mobilizes Ca2+ in anterior pituitary cells. Biochemical and Biophysical Research Communications 139, 1188-1194 (1986). 4.Falck, J.R.,Manna, S.,Moltz, J., et al. Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets. Biochemical and Biophysical Research Communications 114, 743-749 (1983). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥99% deuterated forms (d1-d11) |
| 计算分子量 | 331.5 |
| 分子式 | C20H21D11O3 |
| 稳定性 | ≥ 6 months |
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