| 货号 | 10009532-50ug |
| 描述 | (±)8(9)-EET-d11 contains 11 deuterium atoms at the 16, 16 , 17, 17 , 18, 18, 19, 19, 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of (±)8(9)-EET (Item No. 50351) by GC- or LC-mass spectrometry (MS). (±)8(9)-EET is biosynthesized from arachidonic acid in rat and rabbit liver microsomes by CYP450.1,2 (±)8(9)-EET is a major P450 metabolite in the renal cortex.3 (±)8(9)-EET reduces GFR through cyclooxygenase-dependent preglomerular vasoconstriction.4 |
| 别名 | (±)8(9)-EET8(9)-EpETrE-d11; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Chacos, N.,Falck, J.R.,Wixtrom, C., et al. Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid. Biochemical and Biophysical Research Communications 104, 916-922 (1982). 2.Oliw, E.H.,Guengerich, F.P., and Oates, J.A. Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. The Journal of Biological Chemisty 257, 3771-3781 (1982). 3.Zhang, J.Y.,Prakash, C.,Yamashita, K., et al. Regiospecific and enantioselective metabolism of 8,9-epoxyeicosatrienoic acid by cyclooxygenase. Biochemical and Biophysical Research Communications 183, 138-143 (1992). 4.Katoh, T.,Takahashi, K.,Capdevila, J., et al. Glomerular stereospecific synthesis and hemodynamic actions of 8,9-epoxyeicosatrienoic acid in rat kidney. American Journal of Physiology 261, F578-F586 (1991). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% deuterated forms (d1-d11) |
| 计算分子量 | 331.5 |
| 分子式 | C20H21D11O3 |
| 稳定性 | ≥ 1 year |
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