| 货号 | 9001902-5g |
| 描述 | 5-Aminolevulinic acid (5-ALA) is a precursor in the biosynthesis of porphyrins, including heme. The conversion of 5-ALA to protoporphyrins within tissues produces a photosensitive target that produces reactive oxygen species upon exposure to light.1 In this way, it is used in photodynamic therapy for a range of dermatological conditions, cancers, and other diseases.1,2,3 Also, oral administration of 5-ALA leads to the preferential accumulation of the fluorescent molecule protoporphyrin IX within certain types of cancer cells.4,5 This allows fluorescence-based identification of tumor tissue for accurate resection of diseased tissue.4,5 |
| 别名 | 5-ALA;δ-Aminolevulinic Acid; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Matei, C.,Tampa, M.,Poteca, T., et al. Photodynamic therapy in the treatment of basal cell carcinoma. J.Med.Life 6(1), 50-54 (2013). 2.Anand, S.,Ortel, B.J.,Pereira, S.P., et al. Biomodulatory approaches to photodynamic therapy for solid tumors. Cancer Letters 326(1), 8-16 (2012). 3.Issa, M.C., and Manela-Azulay, M. Photodynamic therapy: A review of the literature and image documentation. An.Bras.Dermatol. 85(4), 501-511 (2010). 4.Roberts, D.W.,Valdés, P.A.,Harris, B.T., et al. Glioblastoma multiforme treatment with clinical trials for surgical resection (aminolevulinic acid). Neurosurg.Clin.N.Am. 23(3), 371-377 (2012). 5.Zhao, S.,Wu, J.,Wang, C., et al. Intraoperative fluorescence-guided resection of high-grade malignant gliomas using 5-aminolevulinic acid-induced porphyrins: A systematic review and meta-analysis of prospective studies. PLoS One 8(5), e63682 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 167.6 |
| 分子式 | C5H9NO3 • HCl |
| CAS号 | 1297222 |
| 稳定性 | ≥ 2 years |
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