| 货号 | 18602-50g |
| 描述 | While extracellular glutamic acid is an excitatory neurotransmitter, intracellular glutamic acid is an amino acid that serves numerous metabolic roles.1 Dimethyl DL-glutamate is a cell-permeant glutamic acid derivative that enhances insulin release in response to glucose in isolated islets and in animal models of diabetes.2,3 It also potentiates the insulinotropic potential of glyburide (Item No. 15009) and glucagon-like peptide 1.2,3 Dimethyl DL-glutamate is used as a cell-permeable form of glutamate in studies of glutamate action in β-cells.4,5 However, it can be cytotoxic to myeloid cells and act as an antagonist of glutamate-mediated neurosignaling.6,7 |
| 别名 | Glutamic Acid dimethyl ester;Dimethyl 2-aminopentanedioate; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bräuner-Osborne, H.,Egebjerg, J.,Nielsen, E.O., et al. Ligands for glutamate receptors: Design and therapeutic prospects. J. Med. Chem. 43(14), 2609-2645 (2000). 2.Sener, A.,Conget, I.,Rasschaert, J., et al. Insulinotropic action of glutamic acid dimethyl ester. American Journal of Physiology 267(4 Pt 1), E573-E584 (1994). 3.Cancelas, J.,Villaneuva-Peñacarrillo, M.L.,Valverde, I., et al. Potentiation and prolongation of the insulinotropic action of glucagon-like peptide 1 by methyl pyruvate or dimethyl ester of L-glutamic acid in a type 2 diabetes animal model. Endocrine 16(2), 113-116 (2001). 4.Casimir, M.,Lasorsa, F.M.,Rubi, B., et al. Mitochondrial glutamate carrier GC1 as a newly identified player in the control of glucose-stimulated insulin secretion. The Journal of Biological Chemisty 284(37), 25004-25014 (2009). 5.Vetterli, L.,Carobbio, S.,Pournourmohammadi, S., et al. Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase. Molecular Biology of the Cell 23(19), 3851-3862 (2012). 6.Thiele, D.L., and Lipsky, P.E. Spectrum of toxicities of amino acid methyl esters for myeloid cells is determined by distinct metabolic pathways. Blood 79(4), 964-971 (1992). 7.Segal, M. Glutamate antagonists in rat hippocampus. British Journal of Pharmacology 58(3), 341-345 (1976). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 211.6 |
| 分子式 | C7H13NO4 • HCl |
| CAS号 | 13515-99-6 |
| 稳定性 | ≥ 2 years |
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