LY2835219 (methanesulfonate)
货号：
17740-10mg 基本售价：
6160.0 元 规格：
10 mg
产品信息
概述| 货号 | 17740-10mg |
| 描述 | LY2835219 is an orally-bioavailable dual inhibitor of cyclin-dependent kinase 4 (CDK4) and CDK6 (IC50s = 2 and 10 nM, respectively).1,2,3 Through this mechanism, it blocks phosphorylation of retinoblastoma protein, resulting in arrest of cell cycling in the G1 phase. LY2835219 has antitumor action against xenografts when used alone or in combination with other chemotherapeutic compounds.2,3 |
| 别名 | Abemaciclib; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Dickson, M.A. Molecular pathways: CDK4 inhibitors for cancer therapy. Clinical Cancer Research 20(13), 3379-3383 (2014).
2.Gelbert, L.M.,Cai, S.,Lin, X., et al. Preclinical characterization of the CDK4/6 inhibitor LY2835219: In-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine. Investigational New Drugs 32(5), 825-837 (2014).
3.Tate, S.C.,Cai, S.,Ajamie, R.T., et al. Semi-mechanistic pharmacokinetic/pharmacodynamic modeling of the antitumor activity of LY2835219, a new cyclin-dependent kinase 4/6 inhibitor, in mice bearing human tumor xenografts. Clinical Cancer Research 20, 3763-3774 (2014).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 602.7 |
| 分子式 | C27H32F2N8 • CH4O3S |
| CAS号 | 1231930-82-7 |
| 稳定性 | ≥ 2 years |
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