15(S)-Fluprostenol
货号：
16787-10mg 基本售价：
6160.0 元 规格：
10 mg
产品信息
概述| 货号 | 16787-10mg |
| 描述 | (+)-15(R)-Fluprostenol isopropyl ester is a prodrug (Travoprost) which is converted by esterase enzymatic activity in the cornea to yield the corresponding free acid.1 The free acid, (+)-15(R)-fluprostenol, is a potent FP receptor agonist.2 The 15(R)-epimers of most prostaglandins are about 100 times less potent than the natural, 15(S)-isomers. However, the neighboring phenoxy group at C-16 reverses the absolute configuration at C-15 in the fluprostenol series; hence, 15(S)-fluprostenol is less active as an FP agonist than 15(R)-fluprostenol. The biology of 15(S)-fluprostenol has not been widely studied. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Stjernschantz, J., and Resul, B. Phenyl substituted prostaglandin analogs for glaucoma treatment. Drugs of the Future 17, 691-704 (1992).
2.Abramovitz, M.,Adam, M.,Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochimica et Biophysica Acta 1483, 285-293 (2000).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 458.5 |
| 分子式 | C23H29F3O6 |
| CAS号 | 54276-24-3 |
| 稳定性 | ≥ 2 years |
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